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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۴، صفحات ۳۷۰-۳۷۵
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چکیده فارسی مقاله
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عنوان انگلیسی Deep brain stimulation in a rat model of post-traumatic stress disorder modifies forebrain neuronal activity and serum corticosterone
چکیده انگلیسی مقاله Objective(s): Post-traumatic stress disorder (PTSD), one of the most devastating kinds of anxiety disorders, is the consequence of a traumatic event followed by intense fear. In rats with contextual fear conditioning (CFC), a model of PTSD caused by CFC (electrical foot shock chamber), deep brain stimulation (DBS) alleviates CFC abnormalities.Materials and Methods: Forty Male Wistar rats (220–250 g) were divided into 5 groups (n=8) and underwent stereotactic surgery to implant electrodes in the right basolateral nucleus of the amygdala (BLn). After 7 days, some animals received a foot shock, followed by another 7-day treatment schedule (DBS treatment). Next, freezing behavior was measured as a predicted response in the absence of the foot shock (re-exposure time). Blood serum corticosterone levels and amygdala c-Fos protein expression were assessed using Enzyme-linked immunosorbent assay (ELISA) and Western blot, respectively. Furthermore, freezing behaviors by re-exposure time test and general anxiety by elevated plus-maze (EPM) were evaluated. Results: PTSD decreased serum corticosterone levels and increased both amygdala c-Fos expression and freezing behaviors. Therefore, DBS treatment significantly (P< 0.001) enhanced serum corticosterone levels and could significantly (P< 0.001) reduce both c-Fos protein expression and freezing behaviors' duration. However, DBS treatment has no effect on the general anxiety in PTSD rats.Conclusion: We argue that these outcomes might demonstrate the mechanism of DBS treatment, a complete therapeutic strategy, in PTSD patients.
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نویسندگان مقاله | Mina Mokhtari hashtjini
Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran|Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Gila Pirzad Jahromi
Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Seyed Shahabeddin sadr
Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran


| Gholam Hossein Meftahi
Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Boshra Hatef
Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Danial Javidnazar
Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_10327.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-576123.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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