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Physiology and Pharmacology، جلد ۱۸، شماره ۴، صفحات ۴۲۹-۴۳۶
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عنوان انگلیسی Effect of ferric sulfate and ferric chloride in controlling liver bleeding an animal model study
چکیده انگلیسی مقاله Introduction: Controlling parenchymal hemorrhage, especially in liver, is still one of the challenges surgeons face with when they try to save the patients’ lives despite improvements in surgical procedures. There is a research contest between the researchers in this field to introduce more effective methods. This study aimed to compare the hemostatic effect of ferric sulfate and ferric chloride on controlling the bleeding from liver parenchymal tissue. Methods: In this animal model study 70 male Wistar rats were randomly allocated into seven groups. An incision, 2 cm long and 0.5 cm deep, was made on each rat’s liver, and the hemostasis time was measured with different concentrations (15%, 25%, and 50%) of either ferric sulfate or ferric chloride compared with the control method (i.e. by simple suturing). The liver tissue was examined for pathological changes after one week. The obtained data were analyzed using Kruskal-Wallis, Mann-Whitney, and Kolmogorov-Smirnov tests in the SPSS software. Results: We found complete hemostasis in all groups. The hemostasis times of different concentrations of ferric sulfate and ferric chloride were significantly less than that of the control group (P value< 0.01). Ferric sulfate showed statistically significant faster hemostasis at different concentrations compared with ferric chloride (P value< 0.01). Conclusion: Ferric sulfate and ferric chloride need less time to control liver bleeding compared to the control method (i.e. by sutures). Ferric sulfate is a more effective hemostatic agent than ferric chloride in controlling hepatic bleeding in an animal model.
کلیدواژه‌های انگلیسی مقاله Hemostasis, Ferric Sulphate, Ferric Chloride, Liver
نویسندگان مقاله سعید نوری | saeed nouri
chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

محمدرضا شریف | mohammad reza sharif
trauma research center, kashan university of medical sciences, kashan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

بردیا جمالی | bardia jamali
chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

یونس پناهی | yunes panahi
chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-764-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacology
نوع مقاله منتشر شده Original Research
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