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Physiology and Pharmacology، جلد ۱۸، شماره ۴، صفحات ۴۵۵-۴۶۵
عنوان فارسی بررسی اثر تزریق داخل هسته پاراژیگانتوسلولاریس کناری ۱۷بتا- استرادیول بر درد حاد و مزمن در موش صحرایی نر
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عنوان انگلیسی Assessing the effect of intra-paragigantocellularis lateralis injection of 17β- estradiol on the acute and persistent pain in the male rat
چکیده انگلیسی مقاله Introduction: 17β-estradiol modulates nociception by binding to estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and GABAA receptors. Beside its autonomic functions, paragigantocellularis lateralis (LPGi) nucleus is also involved in pain modulation. The aim of the current study was to investigate the role of the intracellular estrogenic receptors in the pain modulation by the LPGi nucleus of male rats. Methods: In this study, male Wistar rats in the range of 200-270 gr were used. In order to study the effect of intra- LPGi microinjection of 17β-estradiol on both acute and persistent pain modulation, cannulation of LPGi nucleus was performed. At first, drugs were injected and 15 minutes later 50 μl of 4% formalin was injected into the rat's hind paw. Then formalin-induced flexing and licking behaviours were recorded for 60 min. Results: The results of current study showed that intra-LPGi injection of 17β-estradiol attenuated the flexing and the licking behaviours both in the first phase (P< 0.01) and in the second phase (P< 0.001) of formalin test. The estrogen receptor antagonist (ICI182,780) prevented 17β-estradiol-induced analgesic effect but could not reverse this effect to the control condition, and it had significant difference with the control group, yet. Conclusion: It may be concluded some part of the analgesic effect of 17β-estradiol in the LPGi nucleus on the formalin-induced inflammatory pain is probably mediated by estrogenic receptors.
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نویسندگان مقاله رقیه خاکپای | roghaieh khakpay
dept. of animal sciences, faculty of natural sciences, university of tabriz, tabriz, iran

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

شبنم بارانی | shabnam barani
dept. of animal sciences, faculty of natural sciences, university of tabriz, tabriz, iran

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

حمیرا حاتمی نعمتی | homeira hatami nemati
dept. of animal sciences, faculty of natural sciences, university of tabriz, tabriz, iran

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-439-3&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Pain and addiction
نوع مقاله منتشر شده Original Research
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