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Physiology and Pharmacology، جلد ۱۸، شماره ۴، صفحات ۴۷۷-۴۸۹
عنوان فارسی اثر کندر روی مدل بیماری آلزایمر ناشی از تزریق داخل بطنی استرپتوزوتوسین
چکیده فارسی مقاله
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عنوان انگلیسی Effect of olibanum on a rat model of Alzheimer’s disease induced by intracerebroventricular injection of streptozotocin
چکیده انگلیسی مقاله Introduction: Olibanum improves memory in different models of learning. However, the effect of olibanum on models of Alzheimer’s disease has been less studied. In the present study, the effect of olibanum on memory in normal rats and in a rat model of Alzheimer disease induced by intracerebroventricular injections of streptozotocin was evaluated. Methods: Rats received an aqueous extract of olibanum (50, 100 and 300 mg/kg) via gavage, acutely 30 minutes before the test and chronically for 21 consecutive days before assessment of memory racall. In two other groups of animals, two guide cannulas were inserted into the lateral ventricles under stereotaxic surgery. One group received bilateral injections of streptozotocin (1.5 mg/kg/2 μl/side) in the first and third days of surgery. The other group received artificial cerebrospinal fluid. Fourteen days after surgery, learning was evaluated. Two other groups of animals received olibanum (50 mg/kg) or its solvent, for 21 days beginning from one week before injections of streptozotocin. Results: Acute administration of olibanum did not affect learning parameters, but chronic administration of it (50 mg/kg) improved memory retrieval. Streptozotocin increased number of necessary stimulations for induction of short term memory, but decreased step through latency, significantly. In animals which received streptozotocin, olibanum increased step through latency, significantly. Conclusion: Olibanum reduces the risk of Alzheimer’s disease induced by streptozotocin. Further studies with emphasis on active constituents of olibanum may result in development of drugs capable of decreasing probability of Alzheimer’s disease occurrence.
کلیدواژه‌های انگلیسی مقاله Olibanum, Streptozotocin, Alzheimer disease
نویسندگان مقاله سید رسول ذاکر | seyyed rasoul zaker
division of animal sciences, dept. of biology, faculty of sciences, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

سیامک بهشتی | siamak beheshti
division of animal sciences, dept. of biology, faculty of sciences, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

رضوان آقایی | rezvan aghaie
division of animal sciences, dept. of biology, faculty of sciences, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

مریم نوربخش نیا | maryam noorbakhshnia
division of animal sciences, dept. of biology, faculty of sciences, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-796-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Neurodegeneretive diseases
نوع مقاله منتشر شده Original Research
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