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Iranian Journal of Biotechnology، جلد ۱۶، شماره ۱، صفحات ۸۰-۸۳
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عنوان انگلیسی Sequence Characterization in 3′-Flanking Region of Bovine TNF-α: Association with Milk Production Traits and Somatic Cell Score in Holstein Cattle of Iran
چکیده انگلیسی مقاله Background: Tumor necrosis factor-  (TNF-α) is a cytokine that was identifi ed as a factor with a wide range of proinflammatory activities. The expression of bovine TNF-α in mammary tissue during pregnancy seems to have a role in development of the corresponding glands.Objective: Single nucleotide polymorphisms (SNPs) were defi ned in 3′-fl anking region of bovine TNF-α incattle. Moreover, its association with performance traits in Holstein dairy cattle was evaluated.Materials and Methods: The 3′-fl anking region of TNF-α was screened by single strand conformationpolymorphism (SSCP) and DNA sequencing in Holstein cattle breeds. SAS statistical software was used toanalyze the relationship between diff erent genotypes of amplifi ed fragment with milk production traits (dailymilk yield, fat and protein percentage) and somatic cell score (SCS).Results: A total of 6 distinct SSCP patterns were observed. It was further revealed to be 3 novel SNPs. Statistical analysis revealed that diff erent haplotypes of amplifi ed fragment in the TNF-α 3′-region had a signifi cant effect on average daily milk production (p < 0.05), but no such correlation was established with fat percentage, protein percentage and SCS.Conclusion: The association identifi ed in the 3′-fl anking region of TNF-α may have potential to serve as candidate genetic marker for genomic selection in dairy cattle.
کلیدواژه‌های انگلیسی مقاله Milk production traits,SCS,SNPs,TNF-α,3′-flanking region
نویسندگان مقاله Mustafa Muhaghegh |
Department of Animal Science, Faculty of Agriculture, Yasouj University, Yasouj, Iran

Azam Rahimi Rezaei |
Department of Animal Science, Faculty of Agriculture, Yasouj University, Yasouj, Iran

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