این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Cancer، جلد ۹، شماره ۲، صفحات ۱۳۳-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Salivary Parameters as Predictive Markers for Radiation-induced Treatment Response in Head and Neck Cancers: An Investigational Study
چکیده انگلیسی مقاله Background: This study evaluates the predictive significance of salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase in the treatment of head and neck cancer patients who undergo curative radiotherapy/chemoradiotherapy. Methods: The volunteers for the study included head and neck cancer patients that required curative radiotherapy/chemoradiotherapy. Patients provided saliva and blood samples before the start of radiation treatment and 24 h after the first radiation fraction of 2 Gy (before the start of the second fraction). Samples were assessed for the levels of blood and salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase by standard laboratory methods. Clinical tumor radioresponse was assessed one month after the completion of treatment as complete responders, partial responders, and nonresponders. Results: The results indicated a significant increase in the levels of amylase, lactate dehydrogenase, and lipid peroxides; and a concomitant decrease in the levels of glutathione P< 0.05 - P< 0.0001 in saliva and blood. The correlation between the differences in each biochemical parameter with that of the treatment response showed a significant correlation only for the salivary lactate dehydrogenase (R2=0.25; P< 0.02). Conclusion: The results indicate that salivary lactate dehydrogenase can be a useful predictive marker to ascertain radiation-induced tumor regression in head and neck cancers.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Dipika Jayachander
Department of Biochemistry, Father Miller Medical College, Kankanady, Mangalore, India


| Arnadi Ramachandrayya Shivashankara
Department of Radiotherapy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India


| Mamidipudi Srinivasa Vidyasagar
Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India


| Raees Tonse
Department of Radiation Oncology, Narayana Hrudayalaya, Bengaluru, Karnataka, India


| Sarita Pais
Department of Biochemistry, Father Miller Medical College, Kankanady, Mangalore, India


| Ashwin DL Lobo
Department of Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India


| Sanath Kumar Hegde
Department of Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India


| Suresh Rao
Department of Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India


| Manjeshwar Shrinath Baliga


نشانی اینترنتی http://mejc.sums.ac.ir/index.php/mejc/article/view/866
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/181/article-181-579699.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات