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Iranian Biomedical Journal، جلد ۲۲، شماره ۳، صفحات ۱۵۱-۱۵۹
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عنوان انگلیسی Lipid Peroxidation and Its Role in the Expression of NLRP1a and NLRP3 Genes in Testicular Tissue of Male Rats: a Model of Spinal Cord Injury
چکیده انگلیسی مقاله Background: The majority of male patients with spinal cord injury (SCI) suffer from infertility. Nucleotide-binding oligomerization domain-like receptors NOD-like receptors (NLRs) are a kind of receptors that corporate in the inflammasome complex. Recent studies have introduced the inflammasome as the responsible agent for secreting cytokines in semen. Reactive oxygen species (ROS) is one of the elements that trigger inflammasome activation. Genital infections in SCI can lead to ROS generation. We investigated the relation between lipid peroxidation and inflammasome complex activity in testicular tissue of SCI rats. Methods: Adult male rats (n=20), weighting 200-250 g, were included and divided into four groups: three experimental groups, including SCI1, SCI3, and SCI7, i.e. the rats were subjected to SCI procedure and sacrificed after one, three, and seven days, respectively and a control group. We performed a moderate, midline spinal contusion injury at thoracic level 10. The animals were anesthetized, and testes were collected for measurement of gene expression by real-time PCR. Caudal parts of epididymis were collected for malondialdehyde (MDA) measurement. Results: No NLRP1a mRNA overexpression was seen in the testes of control and SCI groups. After seven days from SCI surgery, NLRP3 mRNA expression was significantly increased in SCI7 animals (p ≤ 0.05). There was a significant difference in MDA level in SCI7 versus control group, as well as SCI1 and SCI3 animals (p ≤ 0.05). Conclusion: NLRP3 overexpression occurs due to the increased ROS production in testis tissue of SCI rats. 
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نویسندگان مقاله | Mahshid Bazrafkan
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Banafsheh Nikmehr
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Abdolhossein Shahverdi
Department of Embryology, Royan Institiute, Tehran, Iran


| Seyed Reza Hosseini
Department of Urology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Fatemeh Hassani
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Mahnaz Poorhassan
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Tahmineh Mokhtari
Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran


| Farid Abolhassani
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Hamid Choobineh
School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran


| Cordian Beyer
Institute of Neuroanatomy, RWTH Aachen University, Aachen, Germany


| Gholamreza Hassanzadeh
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-700&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
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