این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Biomedical Journal، جلد ۲۲، شماره ۳، صفحات ۲۱۰-۲۱۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors
چکیده انگلیسی مقاله Background: Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triple-negative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with luminal breast tumors and its association with the clinicopathologic characteristics of patients. Methods: BRCA1 expression was evaluated by real-time PCR in 26 triple-negative and 27 luminal breast tumors. Results: The results revealed that there is a high frequency of BRCA1 underexpression in both triple-negative and luminal breast tumors. The BRCA1 underexpression was related to young  age at diagnosis, lymph node involvement, and grade ІІІ tumors. Conclusion: The observations suggest that decreased BRCA1 expression, regardless of tumor subtype, has a general role in breast malignancy and associated with poor prognostic features in breast tumors.
کلیدواژه‌های انگلیسی مقاله Breast cancer, BRCA1, Triple-negative breast neoplasm
نویسندگان مقاله | Farzaneh Darbeheshti
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Pantea Izadi
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Amir Nader Emami Razavi
Iran National Tumor Bank, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran


| Mir Saeed Yekaninejad
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| and Javad Tavakkoly Bazzaz


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-671&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-581635.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cancer Biology
نوع مقاله منتشر شده مقاله کوتاه
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات