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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۶، صفحات ۵۷۷-۵۸۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Selenium supplementation in the form of selenium nanoparticles and selenite sodium improves mature male mice reproductive performances
چکیده انگلیسی مقاله Objective(s): The current study was conducted to examine the possible protective and retentive effects of one-week intra-peritoneal (IP) administration of selenium nanoparticles (Se-NPs), compared to its bulk counterpart, selenite sodium (Ss), after one complete cycle of spermatogenesis in mature male mice. Materials and Methods: Thirty adult male mice were divided into 3 groups. Control group was administrated phosphate-buffered saline (IP) and the other groups received Ss (0.50 mg kg-1) and Se-NPs (0.50 mg kg-1) for seven successive days. Then, the animals were monitored for 28 days and finally sacrificed and tissue and blood samples were taken. Histopathological features, sperm quality, in vitro fertilization (IVF) capability and selenium (Se) content in testicular tissue were analyzed. Antioxidant enzyme activities including catalase, glutathione peroxidase, and superoxide dismutase as well as total antioxidant capacity and malondialdehyde levels were assessed in blood and the tissue samples. Results: Remarkable differences were found in sperm characteristics, histopathological features and oxidative stress biomarkers between control and treatment groups. Moreover, IVF evaluation and tissue Se concentration examination weren't similar for Se-NPs and Ss. Conclusion: Conclusively, Se-treated groups had more antioxidant capacity than the control group, but sperm quality and histopathological features revealed that Se-NPs might possess more antioxidative and retentive potential compared to Ss in one spermatogenesis cycle.
کلیدواژه‌های انگلیسی مقاله Mice, Nanoparticle, Selenium, Spermatogenesis, Testis
نویسندگان مقاله | Siamak Asri-Rezaei
Department of Clinical Pathology and Internal Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azerbaijan, Iran


| Alireza Nourian
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azerbaijan, Iran


| Ali Shalizar-Jalali
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azerbaijan, Iran


| Golamreza Najafi
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azerbaijan, Iran


| Ali Nazarizadeh
Department of Clinical Pathology and Internal Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azerbaijan, Iran


| Mobin Koohestani
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azerbaijan, Iran


| Ali Karimi
Ph.D. Student of Histology, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azerbaijan, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_10670.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-585090.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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