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Avicenna Journal of Phytomedicine، جلد ۸، شماره ۳، صفحات ۲۱۰-۲۲۶
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عنوان انگلیسی Effect of Centella asiatica on pathophysiology of mild chronic cerebral hypoperfusion in rats
چکیده انگلیسی مقاله Centella asiatica extract on cognition and hippocampal pathology of mild chronic cerebral hypoperfusion (CCH) that was induced by permanent right common carotid artery occlusion (RCO) in rats. Materials and Methods: Sixty-four male Sprague-Dawley rats were randomly divided into four groups of Sham-veh, Sham-C. asiatica, RCO-veh and RCO-C. asiatica, which were further divided into short-term and long-term CCH induction. Oral treatments with 20 mg/kg C. asiatica initiated 24 hours and 12 months after CCH and continued for 14 consecutive days. According to the cognition and histopathological evaluation period, the experiment was divided into 2 sets of either 2 or 12 months of CCH. Results: Results showed that 2-month CCH induced learning flexibility deficit associated with CA1 neuronal damage and internal capsule (IC) astroglia activation. Long-lasting (12 months) mild CCH induced spatial learning, memory and flexibility deficits associated with progressive dorsal hippocampal damage. Treatment with 20 mg/kg of C. asiatica improved learning flexibility deficit after 2 and 12 months of CCH. C. asiatica ameliorated neuronal damage in the dorsal hippocampus at 2 months of CCH when given 24 hours after CCH onset. Treatment with C. asiatica after 12 months of cerebral blood flow reduction improved memory and learning flexibility deficits and was associated with the dentate gyrus neuronal damage reduction. Conclusion: Our finding indicates the therapeutic potential of C. asiatica either when given immediately after ischemic insult or when administered one year after ischemic insult, in a CCH rat model.
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نویسندگان مقاله | Wachiryah Thong-asa
Animal Toxicology and Physiology Specialty Research Unit (ATPSRU), Physiology Division, Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand


| Kanokwan Tilokskulchai
Neuroscience Unit, Department of Physiology, Faculty of Medicine Siriraj, Siriraj Hospital, Mahidol University, Bangkok, Thailand


| Supin Chompoopong
Department of Anatomy, Faculty of Medicine Siriraj, Siriraj Hospital, Mahidol University, Bangkok, Thailand


| Mayuree Hantrakul Tantisira
Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand
نشانی اینترنتی http://ajp.mums.ac.ir/article_9854.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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