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Iranian Biomedical Journal، جلد ۲۲، شماره ۴، صفحات ۲۱۷-۲۳۰
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عنوان انگلیسی Molecular Signaling in Tumorigenesis of Gastric Cancer
چکیده انگلیسی مقاله Gastric cancer (GC) is regarded as the fifth most common cancer and the third cause of cancer-related deaths worldwide. Mechanism of GC pathogenesis is still unclear and relies on multiple factors, including environmental and genetic characteristics. One of the most important environmental factors of GC occurrence is infection with Helicobacter pylori that is classified as class one carcinogens. Dysregulation of several genes and pathways play an essential role during gastric carcinogenesis. Dysregulation of developmental pathways such as Wnt/β-catenin signaling, Hedgehog signaling, Hippo pathway, Notch signaling, nuclear factor-kB, and epidermal growth factor receptor have been found in GC. Epithelial-mesenchymal transition, as an important process during embryogenesis and tumorigenesis, is supposed to play a role in initiation, invasion, metastasis, and progression of GC. Although surgery is the main therapeutic modality of the disease, the understanding of biological processes of cell signaling pathways may help to develop new therapeutic targets for GC.
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نویسندگان مقاله | Fatemeh Molaei
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Mahdi Forghanifard
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran


| Yasaman Fahim
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Reza Abbaszadegan
Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-725&slc_lang=fa&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-590015.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Cancer Biology
نوع مقاله منتشر شده Study Break
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