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The Archives of Bone and Joint Surgery، جلد ۶، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی High Serum Alpha-2-macroglobulin Level in Patients with Osteonecrosis of the Femoral Head
چکیده انگلیسی مقاله Background Diagnosis of osteonecrosis of the femoral head (ONFH), a disabling and devastating condition, is complicated by the lack of reliable serum biomarkers. This study aimed to investigate whether the serum level of alpha-2-macroglobulin (A2M) can be used for ANFH diagnosis. Methods Blood samples from 36 ONFH patients were obtained. Serum protein capillary electrophoresis was performed on the sera of the patients. The serum levels of A2M were also subjected to be measured by A2M human enzyme-linked immunosorbent assay. Results Serum protein capillary electrophoresis of ONFH patients revealed that the level of alpha-2 subunit, composed of alpha-2-macroglobulin, ceruloplasmin and 2-2 haptoglobin phenotype, was increased significantly as compared to healthy subjects (p value: 0.0001). Moreover, alpha-2-macroglobulin ELISA assay proved that the A2M has been significantly raised (p value: 0.037). Conclusion Taken together, these findings suggest that avascular necrotic femur head presumably directly or indirectly elevates A2M into the bloodstream. Thus, measuring the serum level of A2M might be used as a reliable diagnostic tool in clinical practice.
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نویسندگان مقاله | Zari Naderi Ghale-Noie
Department of Medical Genetics, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mohammad Amin Kerachian
Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mohammad Hassani
Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Amir R. Kachooei
Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
نشانی اینترنتی http://abjs.mums.ac.ir/article_10280.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده RESEARCH PAPER
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