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Physiology and Pharmacology، جلد ۱۵، شماره ۴، صفحات ۵۷۲-۵۸۲
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Effect of pre-treatment with oxytocin on cardiac enzymes in regional ischemiareperfusion injury induced in the rat heart
چکیده انگلیسی مقاله Introduction: Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT) induced cardioprotection and its signaling pathways on lactate dehydrogenase (LDH) and creatine kinase-MB isoenzyme (CK-MB) in the anesthetized rats. Methods: Eighty-four rats were divided into fourteen groups. Animal’s hearts were subjected to 25 min ischemia and 2 h reperfusion (I/R). Oxytocin (0.03 μg/kg) was used 25 min prior to ischemia. Atosiban, an OT receptor antagonist (1.5 μg/kg), 5-hydroxydecanoic acid, an inhibitor of mitochondrial ATP-dependent potassium channel (10 mg/kg), atractyloside, an opener of mitochondrial permeability transition pores (5 mg/kg), chelytraine, a protein kinase C inhibitor (5 mg/kg) and N-acetylcysteine, a reactive oxygen species scavenger (200 mg/kg) were used 10 min prior to OT administration. Then, LDH and CK-MB levels in plasma were measured. Results: OT administration significantly decreased CK-MB and LDH levels compared to I/R group. Administration of atosiban, 5-hydroxydecanoic, atractyloside, chelytraine and N-acetylcysteine abolished the cardiac preconditioning effect of OT. Conclusion: The present study demonstrates that oxytocin cardioprotective effects are complex and its signaling pathways may mediate through mKATP channels, mPTP, PKC activation and increase ROS.
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نویسندگان مقاله علی محمد علیزاده | ali mohammad alizadeh
tehran, bolvarkeshavarz, instute cancer, cancer reseach center


مهدیه فقیهی | mahdieh faghihi
tehran, keshvarz bolvar,school of medicine, tehran university of medical science

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

وحید خوری | vahid khori
gorgan ,golestan cardiovascular research center, golestan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

مریم محسنی کیا | maryam mohsenikia
tehran, bolvarkeshavarz, instute cancer, cancer reseach center
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-505-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cardivascular system
نوع مقاله منتشر شده Original Research
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