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Physiology and Pharmacology، جلد ۱۵، شماره ۳، صفحات ۲۹۵-۳۰۷
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عنوان انگلیسی Role of nitric oxide on the electrophysiological properties of isolated rabbit atrioventricular node by extracellular field potential during atrial fibrillation
چکیده انگلیسی مقاله Introduction: The aim of the present study was to determine direct effects of NO modulation on protective electrophysiological properties of atrioventricular node (AV node) in the experimental model of AF in rabbit. Methods: Isolated perfused rabbit AV nodal preparations were used in two groups. In the first group (N=7), LNAME (50μM) was applied. In the second group (N=12), different concentrations of L - argenine (250 μM - 5000 μM) were added to the solution. Programmed stimulation protocols were used to quantify AV nodal conduction time, refractoriness and zone of concealment. AF protocol was executed by software with coupling intervals (ranging from 75 – 125 msec). Results: L-NAME had depressive effects on basic AV nodal properties. L-Arginine (250μM) had direct inhibitory effects on nodal conduction time, Wenckebach and refractoriness. Significant increases in the number of concealed beats were induced by L-Arginine (500 μM ). Number of concealed beats were increased from 700.7 ± 33.7 to 763 ±21 msec (P< 0.05). Trend of zone of concealment prolongation in a frequency-dependent model was abrogated by Larginine (250, 5000 μM). Conclusion: NO at low concentration (in the presence of L-NAME) had facilitatory role on AV nodal properties, but at high concentration (in the presence of L-arginine) enhanced protective role of AV node during AF. Biphasic modulatory role of NO may affect protective behavior of AV node during AF.
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نویسندگان مقاله وحید خوری | vahid khori
golestan cardiovascular research center


علی محمد علیزاده | alimohammad alizadeh
cancer research center tehran university of medical sciences tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آمنه نواییان | ameneh navaiyan
golestan cardiovascular research center


محسن نایب پور | mohsen nayebpour
tehran university of medical sciences tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مونا porabouk | mona porabouk
golestan cardiovascular research center


فخری بداغ آبادی | fakhri badaghabadi
golestan cardiovascular research center


شیما چنگیزی | shima changizi
golestan cardiovascular research center


مریم رجایی | maryam rajaei
golestan cardiovascular research center


حمیدرضا مهیمنی | hamidreza moheimani
golestan cardiovascular research center


حمیدرضا یزدی | hamidreza yazdi
golestan cardiovascular research center
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-245-10&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cardivascular system
نوع مقاله منتشر شده Original Research
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