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Physiology and Pharmacology، جلد ۱۵، شماره ۳، صفحات ۴۱۵-۴۲۶
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عنوان انگلیسی Assesment of flaxseed on oxidative stress in prepubertal rats with experimental varicocele
چکیده انگلیسی مقاله Introduction: Perepubertal varicocele can result in hypotrophy of testes, sperm damage and decrease the function of leydig cells in future. pathophysiology of varicocele is unclear. Increased reactive oxygen species (ROS) is a major theory. There are many controversies in treatment of pediatric varicocele. Flaxseed (FS) is the richest source of lignans with antioxidant properties. The aim of this study was to investigate effect of flaxseed on oxidative stress in prepubertal rats with experimental varicocele. Methods: 35 male prepubertal rats were divided into 5 groups: control, sham, sham that fed base diet which was supplemented with 10% FS, varicocele, varicocele that fed base diet which was supplemented with 10% FS. Animals were sacrificed six weeks later. Sperm superoxide anion and H2O2 production, MDA in testis and total antioxidant capacity in semen were evaluated. Results: Intracellular superoxide anion and H2O2 production was significantly higher in varicocele induced group (P≤0.001), but FS significantly decreased them (P≤0.001). There was no significant difference for seminal plasma total antioxidant activity among all groups (P≥0.05). Left testicular MDA concentration of rats with varicocele that were fed by FS 10% was lower compared with varicocele groups (P≤0.05). Conclusion: Fs as a fat soluble antioxidant can protect the sperm membrane from the damage induced by ROS through its effective antioxidant potential.
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نویسندگان مقاله شهلا سهرابی پور | shahla sohrabipour
dept. physiology, faculty of medical sciences, tehran university of medical science, tehran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

عادله جعفری | adele jafari
dept. physiology, faculty of medical sciences, shahid beheshti university of medical science , tehran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

محمد کمالی نژاد | mohamad kamalinejad
dept. pharmacogenosy,, faculty of pharmcy, shahid beheshti university of medical science , tehran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

عبدالفتاح sarrafnejd | abdolfatah sarrafnejd
. dept. pathobiology , faculty of public health, tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

طاهره shahrestany | taherah shahrestany
. dept. pharmacogenosy,, faculty of pharmcy, shahid beheshti university of medical science , tehran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

حمیدرضا صادقی پور | hamid reza sadeghipour
dept. physiology, faculty of medical sciences, tehran university of medical science, tehran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-527-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Endocrinology
نوع مقاله منتشر شده Original Research
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