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Physiology and Pharmacology، جلد ۱۵، شماره ۲، صفحات ۱۶۴-۱۷۲
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Effect of lactation on the expression of gonadotropin-inhibitory hormone in dorsomedial and paraventricular nuclei of the rat hypothalamus
چکیده انگلیسی مقاله Introduction: Gonadotropin inhibitory hormone (GnIH) is believed to be an inhibitor of gonadotropin releasing hormone (GnRH) secretion. The role of GnIH in lactational inhibition of gonadotropin secretion is not well known therefore, the aim of the present study was to evaluate the effect of lactation on expression of GnIH in these nuclei of lactating and non-lactating rats. Methods: Ten postpartum rats of the Sprague-Dawley strain were randomly allotted into two groups. The number of pups was adjusted to five pups per suckling female, while the control non-lactating rats were separated from their pups immediately upon parturition. The lactating rats were allowed to suckle their pups for eight days. The number of GnIH neurons in the dorsomedial (DMH) and paraventricular (PVN) nuclei was estimated using an immunohistochemical method. Results: The number of GnIH neurons in DMH (P=0.005) and PVN (P=0.001) of lactating rats were significantly higher than those of the non-lactating rats. Moreover, fibers of GnIH neurons were observed in anteroventral periventricular nucleus (AVPV) in lactating rats. Conclusion: Lactation increased GnIH expression in DMH and PVN of the lactating rats, and thus may have a role in inhibiting GnRH and subsequently LH secretion during the lactation period.
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نویسندگان مقاله حامد اداوی | hamed adavi
college of agriculture, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

محمدرضا جعفرزاده شیرازی | mohammad reza jafarzadeh shirazi
college of agriculture, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

محمد جواد ضمیری | mohammad javad zamiri
college of agriculture, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

محمدرضا نام آور | mohammad reza namavar
shiraz university of medical sciences, school of medicine, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نادر تنیده | nader tanideh
school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

امین تمدن | amin tamadon
school of veterinary medicine, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-393-4&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Endocrinology
نوع مقاله منتشر شده Original Research
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