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Physiology and Pharmacology، جلد ۱۵، شماره ۲، صفحات ۱۷۳-۱۸۱
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عنوان انگلیسی Dynamic age-related changes of extracellular field potential of isolated AV-node of rabbit
چکیده انگلیسی مقاله Introduction: Developmental changes in atrioventricular nodal conduction time and refractoriness have been shown in several studies. Prevalence of atrioventricular nodal reentrant tachycardia (AVNRT) is clearly age-dependent. The purpose of this study was to determine developmental changes of basic and frequency-dependent electrophysiological properties of the atrioventricular node (AV-node) in neonatal and adult rabbits. Methods: In this study, the effects of increasing age on the basic and rate-dependent properties of isolated perfused AV-node were analyzed in neonatal (2-week-old) and adult (12-week-old) New Zealand rabbits. Specific stimulation protocols of recovery, facilitation and fatigue were separately applied in each group (n=7). Unipolar extracellular field potential was recorded by a silver electrode (100 M). Results: The results showed that the basic nodal properties (ERP, FRP, WBCL and AHmax) were significantly shorter in neonates compared to the adult group. The magnitude of fatigue was also decreased in the neonatal group compared to control (18.9 ±3.3 vs. 11.1 ± 1.2 msec). Time constant of recovery of the adult group was significantly higher than the neonatal group (P< 0.05). Conclusion: The results of this study showed that nodal basic and frequency-dependent properties are age-related and different developmental changes of slow and fast pathways are responsible for this behavior and may reveal the grater susceptibility of AVNRT in young adults compared to infants.
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نویسندگان مقاله وحید خوری | vahid khori
golestan cardiovascular research center


علی محمد علیزاده | alimohammad alizadeh
ehran university of medical science


مهسا نیکنام | mahsa niknam
golestan cardiovascular research center


حمیدرضا مهیمنی | hamid reza moheimani
golestan cardiovascular research center


حمید یزدی | hamid yazdi
golestan cardiovascular research center


مونا پورابوک | mona pourabouk
golestan cardiovascular research center


فخری بداغ آبادی | fakhri badaghabadi
golestan cardiovascular research center


شیما چنگیزی | shima changizi
golestan cardiovascular research center


مریم رجایی | mryam rajaei
golestan cardiovascular research center


محسن نایب پور | mohsen nayebpour
tehran university of medical science

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-245-8&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cardivascular system
نوع مقاله منتشر شده Original Research
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