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Physiology and Pharmacology، جلد ۱۵، شماره ۲، صفحات ۱۹۰-۲۰۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Exposure to Predator Stress in Gestational Period Potentiates Pilocarpine induced Epileptic Behaviors in offspring of rat
چکیده انگلیسی مقاله Introduction: Gestational stress can lead to cerebral functional disorders, such as epilepsy, probably due to the disturbance in the cerebral maturation and causing abnormal neuronal correlations. In the present study, effect of gestational Predator Stress on the neonatal epileptic behaviors was investigated in rats. Methods: Female rats (200 ± 20 g) were divided into two groups intact pregnant rats (control group) and stressed pregnant rats (stressed group). In the stressed group, on gestational days 15, 16, and 17, caged rats were exposed to the cage of a cat for 2 h, once a day. On postnatal day 25, pilocarpine (150 mg/kg s.c.) was injected to pups of both groups, to induce seizure. Then, epileptic behaviors of each pup was observed and recorded. Results: Mean duration of onset of the first neonatal epileptic behavior of the control group was 5.35 ± 0.57 minutes which was decreased to 3.18±0.24 minutes in the stress group. The mean duration of tonic-clonic attacks was significantly increased from 0.53 ±0.1 minute in the control group to 16±3.8 minutes in the stressed group. Moreover, mortality rates during attacks and the level of corticosterone hormone in both mothers and pups showed a significant increase in the stressed group in comparison to the control. Conclusion: Gestational stress can enhance epileptic behaviors in the offspring of rats. Further investigation is required to clarify the underlying mechanism.
کلیدواژه‌های انگلیسی مقاله words, Predator Stress, Seizure, Pilocarpine, Prenatal, Rat
نویسندگان مقاله احسان صبوری | ehsan saboory
urmia, nazlo road, faculty of medicine, department of physiology


شیوا روشن میلانی | shiva roshan milani
urmia, nazlo road, faculty of medicine, department of physiology


رامین احمدزاده | ramin ahmadzadeh
department of biology,faculty of science, payame noor university of isfahan,khomeini shahr

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

علی اصغر پیله وریان | ali asghar pilehvarian
department of biology,faculty of science, payame noor university of isfahan,khomeini shahr

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-144-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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