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Physiology and Pharmacology، جلد ۱۵، شماره ۲، صفحات ۲۱۰-۲۲۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Interaction of colchicine with nitric oxide in CA1 on the expression of drug seeking behavior induced by morphine
چکیده انگلیسی مقاله Introduction: According to previous studies, colchicine causes neuronal destruction and learning depression. In this project, effects of colchicine injection into the CA1 and interaction between colchicine and nitric oxide (NO) in this area on the expression of drug-seeking behavior were investigated. Methods: Wistar rats (250-300 g) were bilaterally cannulated at the CA1 area. Colchicine (2-8 μg/rat) was bilaterally administered after the placement of the cannulas and the treated animals were then allowed to recover for about 1 week before behavioral measurements began. Place conditioning was induced by morphine (2.5-5 mg/kg/day, s.c.) and conducted using a five-day schedule of an unbiased task including familiarization, conditioning and testing. NO agents were injected into the CA1 on the day of the testing and the data were analyzed by ANOVA after reviewing the data recorded by Ethovision. Results: Colchicine significantly reduced the drug-seeking behaviors but morphine caused an increase in these behaviors of colchicine treated rats. NO agents did not show any significant effect except for the compartment entering. Conclusion: Colchicine may decrease the CA1 neural cell population but morphine increases the signs through a mechanism, which is probably dopamine dependent. The NO agents may produce the effects by dopamine due to induction of morphine.
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نویسندگان مقاله سهیلا porkhodadad پورخداداد | soheila porkhodadad pourkhodadad
dept. biology, faculty of basic sciences, shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

منیژه کرمی کرمی | manizheh karami karami
dept. biology, faculty of basic sciences, shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

محمدرضا جلالی ندوشن | mohammad reza jalali nadoushan
dept. pathology, school of medicine, shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-445-2&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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