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Physiology and Pharmacology، جلد ۱۵، شماره ۲، صفحات ۲۸۸-۲۹۴
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Effects of regular swimming exercise on the pain threshold following withdrawal syndrome in morphine-dependent rats
چکیده انگلیسی مقاله Introduction: Nowadays Opioids are gaining acceptance for the management of moderate to severe and chronic pain. In addition, a number of studies have shown that plasma levels of β-endorphin (βEP) in exercise trained are higher than sedentary rats. In our study we assume that exercise training can reduce pain after withdrawal syndrome in morphine-dependent rats. Methods: Male Wistar rats (250±20 g, N=24) were addicted by morphine sulfate 0.4mg/ml (for 21 days) and animals were submitted to swimming training, five days a week for 8 weeks, in which First 60 minutes for 3 weeks and then 90 minutes in two weeks and at the end 120 min for 3weeks. At the end of each stage of exercise protocol naloxan hydrochloride (3mg/kg.ip) was injected. Tail-flick was used to assess the effect of training on nociceptive threshold. Results: Data showed that swimming aerobic exercise significantly increased pain threshold in trained control and addicted rats (p< 0.05) while pain responses did not significantly change in sedentary control and addicted rats. Conclusion: Our results indicate that swimming training has analgesic property in morphine withdrawal-induced hyperalgesia in rats. Therefore, it can be used for the treatment and/or management of painful conditions.
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نویسندگان مقاله فرزانه یادگاری | farzana yadegari
bu ali sina university

سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)

علی حیدریان پور | ali heidarianpour
department of physical education and sport sciences, bu ali sina university,hamedan,iran

سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)

فرزاد ناظم | farzad nazem
bu ali sina university

سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)

| parviz shahabi
department of physiology, faculty of medical sciences, tarbiat modares university, tehran, ir, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-210-2&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pain and addiction
نوع مقاله منتشر شده Original Research
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