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Physiology and Pharmacology، جلد ۱۴، شماره ۳، صفحات ۲۳۴-۲۴۱
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عنوان انگلیسی Alterations of the expression of RGS4 and RGS10 proteins in the anticonvulsant effects of low frequency stimulation on perforant path kindling in adult male rats
چکیده انگلیسی مقاله Introduction: Application of low-frequency stimulation (LFS) is a new method for treatment of drug resistant epileptic patients. Previous studies demonstrated that activation of receptors coupled to Gi proteins is one of the mechanisms of the anticonvulsant effect of LFS. Thus, in this study, alterations in the expression of RGS4 and RGS10 proteins, as negative regulators of Gi proteins, were investigated. Methods: Animals were kindled by perforant path stimulation in a rapid kindling manner (12 stimulation per day, 1 ms pulse duration at 50 Hz). LFS (8 stimulation per day, 0.1 ms pulse duration at 1 Hz, 200 pulses) was applied to the perforant path 5 minute after the termination of kindling stimulations. After electrophysiological recordings for 6 days, the dentate gyrus of the animals was removed and RGS4 and RGS10 protein expression was studied by western blotting technique. Results: Application of LFS significantly retarded kindling acquisition and increased the number of stimulations to achieve different stages of seizure. LFS also significantly reduced after discharge duration. In addition, application of LFS after kindling stimulation reduced the expression of RGS4 and RGS10 proteins. Conclusion: Results of the present study showed that LFS has anticonvulsant effects on the perforant path kindling. Application of LFS following kindling stimulation reduced the expression of RGS4 and RGS10 proteins. Reduction of the expression of these proteins results in the longer activation of signaling pathways of Gi proteins, which may be responsible for LFS anticonvulsant effects.
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نویسندگان مقاله سیمین نامور | simin namvar
department of physiology, faculty of medical sciences, tarbiat modares university

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

جواد میرنجفی زاده | javad mirnajafi zadeh
department of physiology, faculty of medical sciences, tarbiat modares university

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

محمد جوان | mohammad javan
department of physiology, faculty of medical sciences, tarbiat modares university

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

مریم زراعتی | maryam zeraati
department of physiology, faculty of medical sciences, tarbiat modares university

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-51-12&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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