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Physiology and Pharmacology، جلد ۱۴، شماره ۳، صفحات ۲۶۸-۲۸۰
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عنوان انگلیسی Effect of Matricaria recutita L. aqueous extract on acetic acid-induced ulcerative colitis in adult male rats
چکیده انگلیسی مقاله Introduction: Ulcerative colitis is a chronic inflammation of the large intestine (colon). In patients with ulcerative colitis, ulcers and inflammation of the inner lining of the colon lead to symptoms such as abdominal pain, diarrhea, and rectal bleeding. Previous studies have shown that Matricaria recutita L. have a series of physiological effects for example spasmolytic, carminative, antioxidant and anti-inflammatory. In the present study, the effect of this herbal aqueous extract on a model of acute experimental colitis was evaluated. Methods: Experiments were performed on 5 groups (N=7) of male NMRI rats (230-280g). Three groups were administered orally different doses of extract (10, 20 and 30 mg/kg), fourth group received vehicle and the last considered as control group. For induction of colitis the rats were fasted for 36 hours and then anaesthetized with ether, at the last stage 2 ml of acetic acid 4% was instilled via the anus. After 24 hours the macroscopic study showed the colitis indices. Results: The aqueous extract of M. recutita with doses of (20 and 30 mg/kg) significantly reduced colon weight/length ratio. Extract with the highest dose (30 mg/kg) was effective to decrease as well as inflammation severity and extent. The histopathological studies of colon section showed that, curing or treating effects of extract 10, 20, and 30 mg/kg is mild, moderate and completely, respectively. Conclusion: It is concluded that Matricaria recutita L. aqueous extract was effective in treatment against experimental acute colitis. It can decrease inflammatory indices of ulcerative colitis.
کلیدواژه‌های انگلیسی مقاله Ulcerative colitis, Matricaria recutita, Acetic acid, Rat
نویسندگان مقاله یاسر معصومی اردکانی | yaser masoumi ardakani
department of biology, faculty of sciences, shahid bahonar university of kerman, iran

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

مهدی عباس نژاد | mehdi abbasnejad
department of biology, faculty of sciences, shahid bahonar university of kerman, iran

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

امین درخشانفر | amin derakhshanfar
department of pathobiology, faculty of veterinary medicine, shahid bahonar university of kerman, iran

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

خدیجه اسماعیل پور بزنجانی | khadije esmaeilpour bezenjani
department of biology, faculty of sciences, shahid bahonar university of kerman, iran

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

علی مصطفوی | ali mostafavi
department of chemistry, faculty of sciences, shahid bahonar university of kerman, iran

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-377-2&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Gastrointestinal system
نوع مقاله منتشر شده Original Research
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