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Physiology and Pharmacology، جلد ۱۴، شماره ۳، صفحات ۲۸۱-۲۸۷
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عنوان انگلیسی Effect of aqueous extract of Drosera Spatulata on firing rate of paragigantocellularis nucleus neurons after pain induction by formalin in rats
چکیده انگلیسی مقاله Introduction: Previously, we demonstrated that i.p. injection of aqueous extract prepared from aerial parts of Drosera Spatulata (Droseraceae) can induced remarkable analgesia in both phases of formalin test in rats. Because, analgesia induced in acute phase of formalin test mainly mediated by activation of central analgesic mechanisms and also paragigantocellularis (PGi) nucleus is part of brain descending pain control systems the role of this nucleus in analgesic action of the extract on acute pain studied by its effect on PGi neural activity that augmented by injection of formalin to contralateral hind paw of anesthetized rats. Methods: Firing rate of PGi neurons by extracellular single unit recording technique were recorded in 20 urethane anesthetized (1.2- 1.5 g/kg, i.p.) male rats in control, Drosera extract (0.05 mg/kg, i.p.) treated and sodium salicylate (300 mg/kg, i.p.) receiving groups. Formalin (50µl, 2%, s.c.) injected 30 min after each of the above treatments to intraplantar surface of hind paw of rats and change in response of opposite PGi neurons was recorded. Data was analyzed by Wilcoxon ranking test. Results: Extract injection increased firing rates in 66.6% of PGi neurons and decreased 16.6% of neurons (p< 0.001), but had no effect on 16.6% of neurons in formalin injected rats. Sodium salicylate treatment decreased significantly firing rates in 50% PGi neurons in formalin pretreated rats (p< 0.001). Conclusion: The relation between PGi neuronal augmentation and analgesia was reported previously. Thus, the augmentations of firing rates in high percent of PGi neurons after the extract injection provide a document about the role of PGi nucleus in reduction of pain in acute phase of formalin test.
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نویسندگان مقاله سحر گلابی | sahar golabi


مجید حسن پورعزتی | majid hassanpour ezati
dept. biology, science school, shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

کامبیز رهام پور | kambiz rohampour


نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-92-2&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pain and addiction
نوع مقاله منتشر شده Original Research
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