| چکیده انگلیسی مقاله |
Background and purpose: Osteoporosis is a multiple disease that is characterized by decrease in bone mass and bone strength. This decrease is more common in postmenopausal women due to decreased estrogen levels. Vitamin D3 plays a pivotal role in skeletal metabolism by binding to nuclear steroid receptors (receptors for vitamin D (VDR)). This study aimed at investigating the relationship between Vitamin D3 receptor polymorphism and estrogen levels in postmenopausal women with severe osteoporosis. Material and methods: The study population were 173 women including 91 postmenopausal women with osteoporosis and 82 women without osteoporosis (control group) aged 45-60 years of old. The study was carried out during 2011-2012. After extraction of genomic DNA from peripheral blood, FokI polymorphism (rs2228570) of the Vitamin D Receptor Gene (VDR) was investigated using polymerase chain reaction with restriction enzyme digestion (PCR-RFLP) method. Also, its relationship with bone mineral density (Bone Mineral Density) BMD, T-score, and Z-score was investigated. Results: According to the results, there was no association between rs2228570 and osteoporosis. We observed significant differences in bone density between the two groups (P< 0.001). Conclusion: According to the findings, the association between genotype polymorphisms of vitamin D3 and osteoporosis is still unknown and other polymorphisms might affect bone density. |
| نویسندگان مقاله |
هاله اخوان نیاکی | haleh akhavan niaki
associate professor, department of anatomy, faculty of medicine, babol university of medical sciences, babol, iran
علوم پزشکی مازندران
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
طیبه شمالی | tayebeh shomali
student of pharmacy, pharmaceutical sciences research center, hemoglobinopathy institute, student research committee, faculty of pharmacy, mazandaran university of medical sciences, sari, iran
علوم پزشکی مازندران
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
محسن آسوری | mohsen asouri
north research center, pasteur institute of iran, amol, iran
علوم پزشکی مازندران
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
سید محمدباقر هاشمی سوته | seyed mohammadbagher hashemi
associate professor, department of immunology, molecular and cell biology research centre, faculty of medicine, mazandaran university of medical sciences, sari, iran
علوم پزشکی مازندران
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
حامد حقی | hamed haghi
phd student in toxicology, school of pharmacy, tehran university of medical sciences, tehran, iran 6 general practitioner, social security organization, sari, iran
علوم پزشکی مازندران
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
محمد خورشیدی | mohammad khorshidi
assiastant professor, department of toxicology and pharmacology, thalassemia research center and pharmaceutical sciences research center, hemoglobinopathy institute, mazandaran university of medical science, sari, iran
علوم پزشکی مازندران
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
رامین عطایی | ramin ataee
lab staff, north research center, pasteur institute of iran, amol iran
ساری دانشگاه علوم پزشکی مازندران، مرکز تحقیقات علوم دارویی، انستیو هموگلوبینموپاتی
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
علی اصغر احمدی | ali asghar ahmadi
north research center, pasteur institute of iran, amol, iran
علوم پزشکی مازندران
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
سعید کاووسیان | saeid kavosian
lab staff, north research center, pasteur institute of iran, amol iran
علوم پزشکی مازندران
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
گالیا امیر بزرگی | galia amirbozorgi
lab staff, north research center, pasteur institute of iran, amol iran
علوم پزشکی مازندران
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
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