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Physiology and Pharmacology، جلد ۱۲، شماره ۴، صفحات ۲۶۱-۲۶۷
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عنوان انگلیسی The effect of maternal hypothyroidism during pregnancy on carbohydrate metabolism in adulthood in rats
چکیده انگلیسی مقاله Introduction: Many of the diseases of adulthood are originated from the intrauterine conditions during fetal life. Because of the importance of thyroid hormones in growth and development of the fetus, the effects of maternal hypothyroidism on carbohydrate metabolism in adulthood was investigated. Methods: Pregnant rats were divided into the fetal hypothyroidism (FH) and the control (C) groups. During the gestational period, propylthiouracil (PTU) dissolved in drinking water (100 ppm) was administered to the FH group, while the C group drank tap water. After delivery and maturation of male neonates, intravenous glucose tolerance test (IVGTT) was performed. For IVGTT tests, catheters were inserted into the femoral vein and artery after anesthesia. The first arterial sample was taken before injections, then the glucose solution was injected and other samples were obtained after 5, 10, 15, 20, 30 and 60 minutes. Plasma glucose and insulin concentrations were measured using the glucose oxidase and an ELISA method, respectively. Results: Plasma glucose concentration 5 min after glucose injection in the FH group (239.2 ± 15.6 mg/dL) was significantly higher than the C group (190.1 ± 4.5 mg/dL, P< 0.05). There was no significant difference in plasma insulin concentrations of the 2 groups. Daily water consumption during the gestation in PTU administered mothers was significantly lower compared to the C group (P< 0.05). The body weight of animals was significantly (P< 0.05) lower in the FH group compared with the C group. Conclusion: Maternal hypothyroidism can alter carbohydrate metabolism during adulthood, which may contribute to the development of diabetes.
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نویسندگان مقاله صالح زاهدی اصل | saleh zahedi asl
endocrine research center, research institute for endocrine sciences, shahid beheshti university m.c tehran,iran po box 19395-4763

سازمان اصلی تایید شده: پژوهشکده علوم غدد درون ریز و متابولیسم (Research institute for endocrine sciences)

حمید فراهانی | hamid farahani
endocrine research center, research institute for endocrine sciences, shahid beheshti university m.c tehran,iran po box 19395-4763

سازمان اصلی تایید شده: پژوهشکده علوم غدد درون ریز و متابولیسم (Research institute for endocrine sciences)

اصغر قاسمی | asghar ghasemi
endocrine research center, research institute for endocrine sciences, shahid beheshti university m.c tehran,iran po box 19395-4763

سازمان اصلی تایید شده: پژوهشکده علوم غدد درون ریز و متابولیسم (Research institute for endocrine sciences)

فرزانه فرجی شهریور | farzaneh faraji shahrivar
endocrine research center, research institute for endocrine sciences, shahid beheshti university m.c tehran,iran po box 19395-4763

سازمان اصلی تایید شده: پژوهشکده علوم غدد درون ریز و متابولیسم (Research institute for endocrine sciences)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-72-3&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Endocrinology
نوع مقاله منتشر شده Original Research
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