این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۱۲، شماره ۴، صفحات ۳۱۴-۳۱۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Oral administration of morphine delays neural plate development in rat embryos
چکیده انگلیسی مقاله Previous studies have shown that morphine administration could inhibit neural tube development in rat embryos and produce behavioral defects in human and animals. In the present study, the effects of maternal morphine consumption on embryonic neural plate development in Wistar rats were investigated. Methods: Twenty-four female Wistar rats (250-300 g) were crossed with males. After pregnancy, the treatment group received 0.1 mg/ml of morphine in drinking water daily (14 ml water/100 g of body weight for each rat), while the control group received tap water. Eight days and 12 hours after the onset of pregnancy, the animals were anesthetized by chloroform and the embryos were taken out surgically. Lengths of embryos were determined by a Caliper. Embryos were fixed in formalin 10% and tissue was processed, sectioned and stained with H&E. The sections were examined for neural plate development by a light microscope and the MOTIC software. Results: Embryonic length in the treatment group was significantly decreased compared with the control group. Neural plate was observed in the control group. Development of neural plate and other embryonic layers (ectoderm, mesoderm and endoderm) were delayed in the treatment group. The ectoderm layer group was poorly developed in embryos exposed to morphine. Conclusion: Morphine consumption during pregnancy could cause a delay in the development of the neural plate as well as the embryonic layers and especially the ectoderm.
کلیدواژه‌های انگلیسی مقاله Development, Neural plate, Embryonic Layers, Morphine.
نویسندگان مقاله شیوا نصیرایی مقدم | shiva nasiraei moghadam
evin, tehran., neuroscience research center, shaheed beheshti university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

حسین بهادران | hossein bahadoran
niavaran, tehran, department of anatomy, faculty of medicine, and behavioral sciences research center, baqiyatallah a.s. university of medical sciences


ساغر سعیدآبادی | saghar saeidabadi
niavaran, tehran, department of physiology and biophysics, faculty of medicine, and applied neuroscience research center, baqiyatallah a.s. university of medical sciences


جمال شمس | jamal shams
evin, tehran, department of psychiatry, faculty of medicine, shaheed beheshti university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

هدایت صحرایی | hedayat sahraei
department of physiology and biophysics, faculty of medicine, and applied neuroscience research center, baqiyatallah a.s. university of medical sciences, p.o.box 19395-6558, tehran, iran.
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-74-50&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pain and addiction
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات