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Physiology and Pharmacology، جلد ۱۲، شماره ۲، صفحات ۸۳-۹۰
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چکیده فارسی مقاله
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عنوان انگلیسی (S)- 3,5-Dihydroxyphenylglycine )an agonist for group I metabotropic glutamate receptors( induced synaptic potentiation at excitatory synapses on fast spiking GABAergic cells in visual cortex
چکیده انگلیسی مقاله Introduction: (S)- 3,5-Dihydroxyphenylglycine (DHPG) is an agonist for group I metabotropic glutamate receptors. DHPG-induced synaptic depression of excitatory synapses on hippocampal pyramidal neurons is well known model for synaptic plasticity studies. The aim of the present study was to examine the effects of DHPG superfusion on excitatory synapses on pyramidal and fast-spiking GABAergic cells (FS-GABA) of layer II/III of mice visual cortex. Methods: Effects of DHPG was examined in visual cortical slices of GAD67-GFP knock-in mice using whole-cell recordings of excitatory postsynaptic potentials (EPSPs) in layer II/III cells evoked by layer IV stimulation. In part of experiments, long term potentiation (LTP) was induced by theta burst stimulation (TBS) paired with postsynaptic depolarization. Results: DHPG induced potentiation of EPSPs of FS-GABA neurons in dose- and use-dependent manners but it has no effect on pyramidal cell excitatory synapses. An antagonist for type 5 metabotropic glutamate receptors (mGluR5) blocked DHPG-induced LTP, while an antagonist for mGluR1 was not effective. This potentiation and TBS-induced LTP occluded each other. Conclusion: Based on important role of FS-GABA cells in cortical neuronal circuit, mGlur5-dependent LTP may play a role in, enhancement or maintenance of synchronized activity of cortical pyramidal neurons.
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نویسندگان مقاله عبدالرحمن صریحی | abdolrahman sarihi
department of physiology, hamadan university of medical sciences, shahid fahmideh avenue, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

علیرضا کمکی | alireza komaki
department of physiology, hamadan university of medical sciences, shahid fahmideh avenue, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

tadaharu tsumoto | tadaharu tsumoto
neuronal circuit mechanism research group, riken brain science institute, wako-shi, saitama, japan
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-155-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cellular and Molecular BioMedicine
نوع مقاله منتشر شده Original Research
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