این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۱۲، شماره ۲، صفحات ۱۳۶-۱۴۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of tamoxifen on testosterone concentration and sperm count in adult male rats
چکیده انگلیسی مقاله Introduction: Tamoxifen is a nonstroidal antiestrogen prescribed for treatment of breast cancer. The aim of this study was to investigate the effect of tamoxifen on testosterone level in the serum and sperm count in the epididymis of adult male Wistar rats. Methods: Three groups of rats received 200, 400 and 600 µg/kg body weight tamoxifen dissolved in solvent (60% ethanol in physiological solution) for 30 consecutive days. The sham group received the solvent and controls did not receive any drug or solvent. 1, 12 and 36 days after treatment, serum testosterone was measured by radioimmunoassay and sperm numbers in the epididymis were counted. Results: Results showed that testosterone concentration in the serum and sperm count in the epididymis significantly decreased in groups which received tamoxifen compared with the control group. The most profound effects were observed in the first samplings of the group which received 600 µg / kg tamoxifen. Conclusion: These findings indicate that tamoxifen decreases the fertilization ability in adult male rats in a dose dependent manner and this effect disappears after a period of time.
کلیدواژه‌های انگلیسی مقاله Tamoxifen, Testosterone, Sperm, Epididymis, Rat.
نویسندگان مقاله شهربانو عریان | shahrbanoo oryan


کاظم پریور | kazem parivar


معصومه اصل روستا | masoumeh asl rousta


نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-110-143&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات