این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۱۲، شماره ۱، صفحات ۶۰-۶۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of bilateral intrahippocampal injection of all–trans retinoic acid on spatial learning in adult male rats.
چکیده انگلیسی مقاله Introduction: Previous studies have shown that vitamin A and its derivatives such as retinoid and all-trans retinoic acid have a crucial role in memory, learning and synaptic plasticity. The receptors of vitamin A are seen in different parts of the brain such as hippocampus, where vitamin A has an important role in learning. In this study, the effect of intrahippocampal (CA1) injection of all – trans retinoic acid on spatial learning was investigated in adult male rats. Methods: 49 adult male rats divided in 7 groups were used. Test groups (1 – 4) received 1μl of all – trans retinoic acid dissolved in DMSO at concentrations of 1, 2, 4 and 8 μg/μl, for 4 consecutive days, 90 minutes before training. Group 5 received DMSO and 6th and 7th groups were designated as sham operation and control (intact) group, respectively. After each injection, Morris Water Maze (MWM) was used as a method to measure learning task. Results: This study showed that all – trans retinoic acid at the concentration of 1 μg/μl improved spatial learning in Morris Water Maze (p< 0.05). Conclusion: Our findings show that all – trans retinoic acid improves spatial learning in rats via enhancing the expression of learning related proteins.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله محمود امینی زاده | mahmoud aminizadeh


مهدی عباس نژاد | mehdi abbasnejad
dept. biology, shaheed bahonar university, kerman, iran

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

احمدعلی معاضدی | ahmad ali moazedi


احمدعلی پاپهن | ahmadali papahn


نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-88-4&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات