این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۱۱، شماره ۴، صفحات ۲۵۲-۲۶۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Assessment of the effect of nitric oxide within hippocampal CA1 area on spatial learning and memory in morphine dependent rats
چکیده انگلیسی مقاله Introduction: There are evidences showing the role of nitric oxide in the opiate reward properties. The role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal CA1 area of rats is also confirmed. It has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of NMDA receptors located in hippocampal CA1 area of rats. The effect of nitric oxide within hippocampal CA1 area on the spatial learning and memory processes in morphine dependent rats is unclear. Methods: 33 N-MRI male rats (250-350 g) were divided into 4 experimental groups. Two cannulae were stereotaxically implanted bilaterally into hippocampal CA1 area. After 5 days recovery, animals received morphine sulfate or sucrose for 30 consecutive days in drinking water. Morris water maze (MWM) studies were performed from day 26 to 30. In this period animals received bilateral intra-hippocampal CA1 injection of 3μg/ 2 μl L-NAME (NOS inhibitor) or 2 μl saline (1 μl/site), 1 min before daily experimentation. Spatial learning and memory parameters were subjected to analysis of variance (ANOVA). Results: Morphine dependence facilitated spatial learning and memory in rats. This effect was inhibited with local administration of L-NAME in hippocampal CA1 area. Conclusion: Activation of intracellular NO signaling pathway in the pyramidal cells of hippocampal CA1 area may involve in facilitating spatial learning and memory in morphine dependent rats.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله علی پورمتعبد | ali pourmotabbed
dept. physiology, school of medicine, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

parychehr یغمایی | parychehr yaghmaei


پرویز ایمانی | parviz imani


سید ارشاد ندایی | seyed ershad nedaei


عاطفه توحیدی | atefeh touhidi


نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-110-142&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات