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Basic and Clinical Cancer Research، جلد ۱۰، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی Methylation Profile of Von Hipple Lindau Gene Promoter in Acute Lymphoblastic Leukemia Patients
چکیده انگلیسی مقاله Background: Epigenetic alteration, with DNA methylation being the major mechanism, can influence gene expression without alteringDNAsequence, which may lead to cancer development. Tumor suppressor genes such as VHL (von Hippel-Lindau) when affected by epigenetic alteration will be silenced. This study investigated DNA methylation of VHL gene in ALL (Acute Lymphoblastic Leukemia) patients with methylation specific PCR (MSP). Methods: DNA of 26 ALL patients and 26 healthy control subject were extracted, treated with bisulfite, and subsequently their VHL gene methylation was analyzed by MSP technique. Results: None of the patients were methylated for VHL gene. Conclusions: Due to the lack of methylation in VHL gene promoter in patients and healthy group, the methylation of this gene cannot be used in diagnosis and prognosis of ALL patients.
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نویسندگان مقاله | Samaneh Ahmadi
Department of Hematology, Faculty of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Shaban Alizadeh
Department of Hematology, Faculty of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Fatemeh Nadali


| Sasan Ghaffari
Department of Medical laboratory sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran


| Mehdi Azad


نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/277
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Brief Communications
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