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Physiology and Pharmacology، جلد ۱۱، شماره ۴، صفحات ۲۸۲-۲۹۲
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عنوان انگلیسی Central mineralocorticoid receptors mediate impairing effects of corticosterone on memory retrieval in rats
چکیده انگلیسی مقاله Introduction: Previous studies have indicated that stress levels of glucocorticoid hormones induce impairment of long term memory retrieval, but the underlying mechanisms (genomic or non-genomic) are not clear. To clarify this issue, we investigated the involvement of brain corticosteroid receptors and protein synthesis in the glucocorticoid-induced impairment of memory retrieval. Methods: 140 young rats were trained in the water maze (WM) task with six trials per day for six consecutive days. Retention of the spatial training was assessed 24 h after the last training session with a 60-s probe trial. Experiments included intraventricular injections of anisomycin ( 187.5 or 450 µg/5µl) , a specific protein synthesis inhibitor or specific antagonists for mineralocorticoid receptors (MR, 37.5, 75, 150 µg/5ul) or glucocorticoids receptors (GR, 75 or 150 µg/5ul) before corticosterone administration (1 mg/kg) shortly before retention testing. Results: The results showed that administration of anisomycin did not change the corticosterone response. Administration of the MR, but not GR, antagonist blocked the corticosterone-induced response. Conclusion: These findings provide evidence for the view that glucocorticoids impair memory retrieval through non-genomic mechanisms involving an interaction with central MRs.
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نویسندگان مقاله مهدی خاکساری | mehdi khaksari
laboratory of learning and memory, department and research center of physiology, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

علی رشیدی پور | ali rashidy pour
laboratory of learning and memory, department and research center of physiology, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

عباسعلی وفایی | abbas ali vafaei
laboratory of learning and memory, department and research center of physiology, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-187-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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