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Physiology and Pharmacology، جلد ۱۱، شماره ۴، صفحات ۲۹۳-۲۹۹
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عنوان انگلیسی Effect of coadministeration of NO and morphine in CA3 of hippocampus on learning and spatial memory in morphine dependent male rats
چکیده انگلیسی مقاله Abstract: ِIntroduction: The effect of morphine dependency on learning and spatial memory is controversial. So in this study effect of co-administeration of nitric oxide (NO) and morphine in CA3 of hippocampus on learning and spatial memory in morphine dependent rats was investigated. Methods: After anaesthetization of male rats, cannulae implanted bilaterally in CA3 of hippocampus. After recovery period (7 days), morphine dependency induced then animals divided in 6 groups that received 1μl saline (Sham), L-Arginine, L-Name and morphine individually and L-Arginine with morphine or L-Name with morphine individually. Morphine dependency was induced by subcutaneous injection of morphine(10mg/kg first day and 20mg/kg for four days). Last dose of morphine(20mg/kg) was injected daily to maintain morphine dependency during test period (5 days) in morris water maze Results: Results showed that L-Name decreased learning in morphine dependent rats although was ineffective on retention of memory. Morphine did not affect learning and spatial memory. Co-administeration of L-Arginine and morphine not only improved the effect of morphine on learning and memory but also promote the effect of L-Arginine on learning and spatial memory. Conclusion: Thus co-administeration of NO and morphine in morphine dependent rats can improve learning and spatial memory differently from using them individually.
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نویسندگان مقاله مهشید حسین زاده | mahshid hoseinzadeh
department of biology, school of science, shaheed bahonar university, kerman, ir.iran

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

ایران پورابولی | iran pouraboli
department of biology, school of science, shaheed bahonar university, kerman, ir.iran

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

مهدی عباس نژاد | mehdi abbasnejad
department of biology, school of science, shaheed bahonar university, kerman, ir.iran

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

بتول پورابولی | batool pouraboli
school of nursing
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-102-2&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pain and addiction
نوع مقاله منتشر شده Original Research
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