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Physiology and Pharmacology، جلد ۱۱، شماره ۴، صفحات ۳۱۲-۳۱۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of amygdala lesion on anterior claustrum kindled seizures in rats
چکیده انگلیسی مقاله Introduction: The claustrum interconnects with the allocortical and neocortical regions and also projects to the hippocampus and the amygdala. .The role of claustrum in the complex partial seizure is not clear. Thus in this study the effect of amygdala lesion on anterior claustrum kindled seizures in rat were investigated. Methods: Male Wistar rats, weighting 250-300 g, were received DC current via a bipolar electrode which is inserted in right basolateral amygdala. A tripolar electrode for stimulation and electroencephalography recording in the right anterior claustrum has been fixed. After a 10 days period of surgical recovery, animals were received kindling stimulation (60Hz, 2s, 1 ms pulse duration) daily, and kindling parameters were measured. In the control group animals did not receive DC current. In the lesion groups (2 groups) animals received DC current both before kindling stimulation and after full kindled statement respectively. Results: Our result showed that amygdala lesion, were capable of delaying claustrum kindling. The delay in kindling was due to an increase in the stimulation trials required to kindle to seizure stages. Furthermore the effect of this lesion on established kindled seizures reduced the severity of claustrum by decrease the stage 5 duration and after discharge duration. Conclusion: amygdale lesion had no effect on the expression of generalized seizures and claustrum play an important role in the propagation of epileptic seizure. Whereas the amygdala has a facilitators role in propagation claustrum kindled seizure.
کلیدواژه‌های انگلیسی مقاله Anterior claustrum, kindling, Amygdala lesion.
نویسندگان مقاله فریبا ظفری | fariba zafari
m.sc student of anatomical sciences, shahid beheshti university of medical sciences.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

معصومه ثابت کسایی | masome sabetkasaei
department of pharmacology, shahid beheshti university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

یوسف صادقی | yousef sadeghi
dapartment of anatomical sciences, shahid beheshti university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

محمد محمدزاده | mohammad mohammad zade
depatment of physiology,tarbiat modares university.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

فاطمه دلجو | fateme deljo
department of pathology, pasture institute.
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-161-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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