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Physiology and Pharmacology، جلد ۱۱، شماره ۳، صفحات ۱۹۹-۲۰۷
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عنوان انگلیسی Effect of aerobic moderate exercise intensity on plasma and aorta homocysteine and 15-F21-isoprostane concentrations in high cholesterol diet-induced atherosclerosis.
چکیده انگلیسی مقاله Few studies have investigated the effect of exercise on homocysteine and 15-F21-isoprostane in animal models. The present study was designed to examine the effect of long-term exercise and/ or high cholesterol diet on MDA, 15-F21-isoprostane and total homocysteine in the aorta and plasma of rabbits. Methods: 56 male rabbits were divided into four groups: normal diet (control), normal diet with exercise, high-cholesterol diet without exercise and high cholesterol diet with exercise. Animals of exercise groups ran on a treadmill at 0.88 km/h for 7.5 –90 min/day (5 days/week) for 12 weeks. At the end of exercise protocol, blood samples were collected and tHcy, 15-F21-isoprostane were measured using enzyme immunoassay (EIA) kits. MDA levels were determined by the thiobarbituric acid assay. Thoracic aorta was isolated to evaluate atherosclerosis as well as tHcy, 15-F21-isoprostane and MDA levels. Results: Exercise reduced atherogenic diet-induced atherosclerotic lesions in aorta along with positive changes in plasma cholesterol profile. Atherogenic diet significantly increased plasma and aorta concentrations of MDA and tHcy. Exercise significantly reduced diet-increased plasma and aorta concentrations of 15-F21-isoprostane and tHcy in normal animals. MDA levels did not show significant change due to exercise and/or high cholesterol diet feeding. There was a positive correlation among plasma cholesterol, homocysteine and 15-F21-isoprostane in exercised groups compared with control. Conclusion: Our results suggest that elevated homocysteine level can be considered as one of the multiple risk factors in the development of atherosclerosis. In addition, exercise may effectively reduce plasma and aorta homocysteine and 15-F21-isoprostane and may be effective in prevention and attenuation of atherosclerosis.
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نویسندگان مقاله محسن علیپور | mohsen alipour
department of physiology,zanjan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

داود سهرابی | davood sohrabi
department of histology,zanjan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

فریدون hydarpour | feridoun hydarpour
department of physiology,zanjan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

رمضان فلاح | ramazan falah
department of social medicine,zanjan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

مصطفی محمدی | mustafa mohammadi
drug applied research center, tabriz university of medical sciences. ‎

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-150-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cardivascular system
نوع مقاله منتشر شده Original Research
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