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Physiology and Pharmacology، جلد ۱۱، شماره ۲، صفحات ۱۲۳-۱۲۹
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عنوان انگلیسی Noradrenergic System Increases Miniature Excitatory Synaptic Currents in the Barrel Cortex
چکیده انگلیسی مقاله Introduction: Neurons in layer II and III of the somatosensory cortex in rats show high frequency (33 ± 13 Hz) of miniature excitatory postsynaptic currents (mEPSCs) that their rates and amplitudes are independent of sodium channels. There are some changes in these currents in neurodegenerative and psychological disorders. Regarding to well known roles of the neuromodulatory brain systems in these disorders, study the effects of these systems on the miniature currents provides data to understand more precisely pathogenesis of this disorders. Because cortical neurons receive very dense noradrenergic innervations, we examined effects of noradrenergic system on these currents. Methods: Whole cell patch clamp recordings were made on pyramidal neurons of the barrel cortex from brain slices that continuously superfused with artificial cerebrospinal fluid (ACSF) containing tetrodotoxin, sodium channel blocker and picrotoxin, blocker of the GABA receptors. Results: Application of noradrenalin significantly increased frequency and decreased amplitude of the mEPSCs. Using specific agonists and antagonists of the noradrenergic system, it was determined that the effects are mostly mediated by α1 receptor. Conclusion: Our results showed that noradrenergic system controls sodium channel independent synaptic transmission which can be of importance in regulation and induction of many physiological and pathophysiological conditions.
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نویسندگان مقاله هاشم حق دوست یزدی | hashem haghdoost yazdi
dept. physiology, qazvin university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

محمدرضا اسماعیلی | mohamad reza esmaili
dept. physiology, qazvin university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

محمد صوفی آبادی | mohamad sophiabadi
dept. physiology, qazvin university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

کریستین stricker | christian stricker
neuroscience division, john curtin school of medical research, australian national university, canberra, australia
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-143-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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