این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۱۱، شماره ۱، صفحات ۱۹-۲۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effects of topiramate on the acquisition and expression of morphine-induced place conditioning and behavioral sensitization in mice
چکیده انگلیسی مقاله Introduction: Topiramate is a newly anti-convulsant drug, which acts as NMDA glutamate receptor antagonist as well as the GABAB receptor agonist. It is used for physical dependence to opioids as well as cocaine, nicotine, alcohol and ecstasy dependence. In the present study attempts were made to further identification of the effects of topiramate on the acquisition and expression of morphine-induced conditioned place preference and behavioural sensitisation in mice. Methods: Male Swiss-Webster mice were used. Conditioned place preference and locomotion were assessed by an un-biased place conditioning paradigm and open filed methods. In a pilot study, the effects of morphine and topiramate on place conditioning paradigm as well as locomotion were assessed in morphine-nave animals for evaluation of effective and ineffective doses of the drugs. Different doses of topiramate were injected to the animals 30 min before each morphine injections (acquisition) or 30 min before the experiments were beginning on the test day. Results: Administration of different doses of morphine (0.5, 5 and 50 mg/kg) induced locomotor activity in the animals. In addition, morphine (1, 10 and 20 mg/kg) administration also induced place preference. On the other hand, administration of different doses of topiramate (20, 80 and 120 mg/kg) neither induced place preference nor altered animals’ activity. Topiramate administration (20 and 80 mg/kg) and (80 and 120 mg/kg) reduced the acquisition and expression of morphine-induced place preference, respectively. In addition, topiramate (20, 80 and 120 mg/kg) reduced the acquisition of morphine-induced behavioral sensitization where as the drug in dose 80 mg/kg enhanced the expression of morphine-induced behavioral sensitization. Conclusion: It can be concluded that topirmate administration interacts with the euphoric and locomotor properties of morphine and this can be considered in therapeutic usage of the drug.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله فاطمه فرخی | fatemeh farokhi


سید سعید پورنقاش تهرانی | seyed said pournaghash tehrani


هدایت صحرایی | hedayat sahraei
dept. psychology, school of psychology, tehran university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

اعظم بختیاریان | azam bakhtiarian


حسن قشونی | hassan ghoshooni


سیده مایده فاطمی | seyedeh maedeh fatemi


جمال شمس | jamal shams


نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-74-5&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات