این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۱۱، شماره ۱، صفحات ۶۸-۷۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی In vitro and in vivo interaction of oral contraceptive high dose (HD) with urine morphine diagnostic test
چکیده انگلیسی مقاله Introduction: Urine morphine test, in several countries is the most primarily available qualitative test for detecting opioid abusers. Since the users of illicit drugs attempt to defeat urine tests and there are also plenty of claims that usage of HD (high dose) contraceptive pills can result in false-negative results, we decided to design the present study to investigate the probable in vitro and in vivo interaction of HD contraceptives and urine morphine diagnostic test. Methods: Several high and low concentrations of ethinylestradiol (EE), levonorgestrel (LN), and both of them were made in the blank urine and urine samples obtained from morphine abusers and then were detected by Acon® urine test strips. Also, high and low doses of EE, LN, and both of them were administered orally to separate groups of control, morphine dependent, and morphine treated (20 mg/kg in single dose, s.c.) male Wistar rats (225 ± 25 g). The urine samples were collected during 3-6, 12-15, 21-24 h time intervals in metabolic cages and were examined by Acon® urine tests. Results: Neither contraceptive constituents nor their urine metabolites at different levels were able to negate the results of urine kits. Conclusion: We conclude that there is no interaction between HD contraceptives and urine morphine diagnostic tests both in vitro and in vivo. It is recommended to inform the results of this study to withhold further misusage of contraceptives and their possible adverse effects.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله ولی اله حاج هاشمی | valiollah hajhashemi
dept. pharmacology and isfahan pharmaceutical research center, school of pharmacy, isfahan univ. med. sci., isfahan.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

محسن میناییان | mohsen minaiyan


مهدی صابریان بروجنی | mahdi saberian boroojeni


نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-110-102&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات