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Physiology and Pharmacology، جلد ۱۰، شماره ۳، صفحات ۱۹۱-۲۰۰
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عنوان انگلیسی The modulatory effects of orexin B on the calcium channels activity in neuronal cells of Helix aspersa (garden snail)
چکیده انگلیسی مقاله Introduction: The functional effects of orexin-B on the calcium spikes and excitability of the neuronal soma membrane of garden snail, Helix aspersa were studied. Methods: Conventional intracellular recording, under the current clamp conditions was performed to examine the effects of orexin-B on the configuration and electrophysiological properties of calcium spikes. Results: Application of orexin-B (300 nM) led to a membrane depolarization and thereby the increase in excitability of neurons. It also decreased the duration and the amplitude of calcium spikes. On the other hand, orexin-B had a dual effect on the amplitude of afterhyper polarization (AHP) in a time dependent manner. The maximum reduction of the amplitude of AHP was recorded within 10 min of orexin-B exposure. However a maximum increase in AHP amplitude was observed later (15 min after exposure to orexin-B). Inactivation of G-proteins by pertussis toxin (100 nM) was used to test the involvement of Gi/Go in the orexin-B induced modulation of calcium channels. Pre-incubation of ganglia for 3-6 h with PTX blocked the depolarization effect of orexin-B on the resting membrane potential. Orexin-B on pretreated neuronal cells with PTX did not statistically change the calcium spike parameters, unless the peak amplitude of AHP increased remarkably. Conclusion: In conclusion, these data suggest that orexin-B (300 nM) may affect the membrane excitability and modulates the activity of calcium and calcium activated potassium channels in snail neurons.
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نویسندگان مقاله علی rastqar | ali rastqar


مهیار جان احمدی | mahyar janahmadi
neuroscience research center and dept. physiology, faculty of medicine, shaheed beheshti


یعقوب فتح الهی | yaghub fathollahi


مهیار جان احمدی | mahyar janahmadi
1neuroscience research center and dept. of physiology, shahid beheshti university medical campus , tehran,iran .

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-25-107&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research
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