این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۱۰، شماره ۲، صفحات ۱۳۵-۱۴۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Olanzapine antagonizes the acquisition and expression of morphine-induced conditioned place preference in male and female mice
چکیده انگلیسی مقاله Introduction: Several investigations have indicated that dopamine D receptors could influence morphine 2 eward. The influence of olanzapine (a D dopamine receptor antagonist) on the morphine-induced conditioned 2 lace preference (CPP) in male and female mice was investigated in the present study. Methods: The effects of olanzapine on the acquisition and expression of morphine CPP in male and female -MRI mice (W: 20-25 g) were investigated in the present study. Resultd: Subcutaneous (s.c.) injection of morphine (1-10 mg/kg, three drug sessions) induced place preference oth in male and female mice. Intraperitoneal (i.p.) administration of olanzapine (0.5-5 mg/kg) induced place version (CPA) in female mice but not in male mice. Administration of olanzapine (1, 2.5, 5 mg/kg, i.p.) reduced oth the acquisition and expression of morphine-induced CPP in male and female mice. However, olanzapine (5 g/kg, i.p.) caused more than 80% mortality in female but not male mice. The effects of olanzapine were reversed y L-arginine (20 mg/kg, i.p.) pre-administration. Conlusion: We conclude that olanzapine reduced morphine effects via different mechanism/s.
کلیدواژه‌های انگلیسی مقاله Morphine, Olanzapine, Place preference, Nitric oxide, Mice.
نویسندگان مقاله پریوش حافظ امینی | parivash hafez amini


جمال شمس | jamal shams


علی shabahng صابر تهرانی | ali shabahng saber tehrani


علی حایری روحانی | ali haeri rohani


کاظم پریور | kazem parivar


وهاب باباپور | vahab babapour


هدایت صحرایی | hedayat sahraei
department of physiology and biophysics, behavioral sciences research center bsrc and military health research center, baqiyatallah a.s. university of medical sciences, tehran, iran
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-74-3&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pain and addiction
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات