این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۱۰، شماره ۱، صفحات ۳-۱۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Sex differences and role of gonadal hormones in development of tolerance to morphine analgesia and glutamate level in the nucleus accumbens of rats: A microdialysis study
چکیده انگلیسی مقاله Introduction: Sex differences are observed in the development of tolerance to antinociceptive effect of opioid drugs such as morphine, but the underlying mechanisms remain unclear. Critical role of glutamate in the development and maintenance of opioid tolerance has been reported by many investigators. There are also evidences about interaction between gonadal hormones and neuromodulatory systems including opioidergic and glutamatergic systems. The present study examined the sex differences and role of gonadal hormones on the glutamate level in the nucleus accumbens in morphine tolerant rats using in vivo microdialysis. Methods: Intact, gonadectoized and sham-operated male and female rats were used. Morphine (7 mg/kg/day, SC) was administered for 8 days. Response to thermal noxious stimuli were measured by tail-flick test. Tolerance was defined as the response which was not significantly different from baseline. Results: The results showed that after chronic morphine administration, antinociceptive tolerance in male rats was significantly greater than females (P< 0.05). Sex differences in morphine tolerance disappeared with gonadectomy of animals. There was also significant sex difference in glutamate level in nucleus accumbens of morphine tolerant rats (P< 0.05), Glutamate level was decreased after ovariectomy of female rats (P< 0.05), but gonadectomy had not significantly effect on glutamate level in males. Conclusion: Results of this study provide evidence of sex differences in development of tolerance to morphine in rats and mediatory roles of gonadal hormones and glutamate levels in these differences.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سیده زهرا موسوی | seyede zahra mosavi


بیژن شفقی | bijan shafaghi


فرزاد کبارفرد | farzad kobarfard


معصومه جرجانی | masoumeh jorjani
neuroscience res. and dept. of pharmacology-faculty of medicine, shaheed beheshti univ. of med. sci.;tehran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-104-1&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات