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Physiology and Pharmacology، جلد ۱۰، شماره ۱، صفحات ۵۷-۶۲
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عنوان انگلیسی Intrathecal administration of epinephrine inhibits and reverses analgesic tolerance to analgesic effect of morphine in rats
چکیده انگلیسی مقاله Introduction: Several researches have reported that stress is able to inhibit the development of morphine tolerance via activating of Hypothalamic-Pituitary-Adrenal (HPA) axis. In the present study we tried to examine the effect of epinephrine, the product of adrenal medulla, on the development of morphine tolerance. Methods: Analgesic tolerance was induced by intrathecal (i.t.) injection of morphine 15 μg/kg, twice a day for 5 days. To study the effect of epinephrine on morphine tolerance, epinephrine (2, 5, 10 or 20 μg/kg, i.t.) was administrated 20 minutes before morphine injection. Analgesia was assessed using tail flick test. Results: In animals that received combined treatments of morphine and epinephrine in doses 2, 5, 10 or 20 μg/ kg for 5 days, at 6th day, morphine produced a more potent analgesia comparing with animals that received saline and morphine during days 1-5. Following tolerance induction during first 5 days, co-administration of epinephrine and morphine during days 6 – 10 reduced the initial tolerance as it induced potent analgesia on day 11th. Conclusion: Our results showed that i.t. administration of epinephrine is able to inhibit and reverse the analgesic tolerance to morphine. It also suggests the possible role of adrenal medulla and epinephrine in mediating the inhibitory effect of stress and HPA activation of the development of analgesic tolerance to morphine.
کلیدواژه‌های انگلیسی مقاله Tolerance, Morphine, Opioids, Epinephrine.
نویسندگان مقاله لیلا ستاریان | leila satarian


محمد جوان | mohammad javan
dept. physiology, school of medical sciences, tarbiat modares univ., tehran, iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

یعقوب فتح الهی | yagoob fathollahi


نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-3-2&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pain and addiction
نوع مقاله منتشر شده Original Research
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