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Physiology and Pharmacology، جلد ۹، شماره ۲، صفحات ۹۹-۱۰۵
عنوان فارسی Effect of electrical lesion of amygdala basolateral-lateral nuclei on the piriform cortex kindled seizures in rats
چکیده فارسی مقاله P Shahabi1, SJ Mirnajafi-Zadeh1, Y Fathollahi1, N Hosseinmardi1, ME Rezvani1, A Eslamifar2 and Z Deljou2Abstract:Amygdala and piriform cortex have critical role in temporal lobe seizures and determination of their precise rolein these kinds of seizures is very important. In this study the effect of electrical lesion of amygdale basolaterallateralnuclei on the piriform cortex kindled seizures was investigated.Rats were kindled by daily electrical stimulation of piriform cortex. In the first experiment fully kindled animalsreceived intra-amygdala 2% lidocaine (for reversal neuronal inhibition) bilaterally. Five min later, animals werestimulated and seizure parameters were measured. In second experiment, the amygdala of kindled animals waslesioned by electrical DC current bilaterally and animals were stimulated 24 h later. Daily stimulations of theseanimals continued for 5 days after lesion.Intra-amygdala lidocaine reduced the kindled seizures severity. There were significant increase in stage 4 latencyand decrease in stage 5 duration. Amygdala lesion reduced the seizures severity more dramatically and all seizureparameters with except to seizure stage were reduced significantly. The significant reduction in seizure parameterswas observed for 4 days after amygdala lesion.The basolateral-lateral amygdala neuronal activity has a critical role in propagation of epileptic seizures frompiriform cortex. Elimination of this activity decreases the severity of piriform cortex kindled seizures. However,this decrease is temporally and several days later (probably because of other brain regions activation) the seizureparameters return to their control values.Keywords: Seizure, Piriform cortex, Amygdala, Electrical lesion, lidocaine. 1. Dept. Physiology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.2. Pasteur Institute, Tehran, Iran.
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عنوان انگلیسی
چکیده انگلیسی مقاله
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نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-51-1&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
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نوع مقاله منتشر شده Original Research
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