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Physiology and Pharmacology، جلد ۹، شماره ۲، صفحات ۱۱۵-۱۲۰
عنوان فارسی Sex difference in morphine withdrawal signs during course of addiction in male and female rats.
چکیده فارسی مقاله H Zangiabadi1, F Motamedi1, P Rostami2, H Manaheji1 and S Danyali11. Dept. Physiology and Neuroscience Research Center, Shaheed Beheshti Univ. Med. Sci., Tehran, Iran.2. Dept. Biology, Tarbiat Moaalem University, Tehran, IranAbstract:There are controversial reports about the sex differences in pain perception and morphine withdrawal signsfollowing acute and chronic morphine administration. Therefore, the difference in withdrawal signs duringtime-courses of induction of morphine addiction is still of interest. In the present study the sex difference inthe perception of acute, chronic and interphase pain of formalin test following chronic morphine administrationfor 10, 15, 20, and 26 days has been investigated. Also the severity of morphine dependence was assessed byobserving withdrawal signs induced by naloxone hydrochloride in different days of addiction process.The addicted and control animals (n=8 per group) received morphine sulfate and sucrose, respectively, in theirdrinking water.Our results showed that acute and interphase pain was higher in female rats receiving morphine for 10, 20, 26 days,in comparison with similar treated male rats but there were not differences in chronic pain perception betweentwo sexes. Some morphine withdrawal signs like abdominal contractions and writhing were significantly higherin female rats but other withdrawal signs including diarrhea, teeth chattering, ptosis, restlessness and weight losswere not different.It may be concluded that the acute and interphase pain of formalin test and some withdrawal signs of addictedfemale rats are higher than addicted male rats. This might be due to differences of central nervous systemsensitivities with respect to morphine consumption in both sexes.Keywords: Sex differences, morphine dependence, withdrawal signs, formalin test.
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نوع مقاله منتشر شده Original Research
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