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Physiology and Pharmacology، جلد ۹، شماره ۲، صفحات ۱۴۳-۱۵۰
عنوان فارسی Protective and therapeutic effects of Curcuma longa powder on the CCL۴ inducedhepatic damage
چکیده فارسی مقاله M Alizadeh, M Fereidoni, N Mahdavi and A MoghimiDepartment of Biology, Ferdowsi Univ., Mashhad, Iran.fereidoni@yahoo.comAbstract:Curcuma longa to treat some diseases such as skin inflammation and trauma, bile disorders, diabetes and cancer, especiallythrough Asia and India. Antioxidant properties and therapeutic effects of turmeric have been reported inseveral literatures. Curcumin as theTurmeric effective substance is used frequently in the investigations butsince people are usually using the turmeric powder, this study was performed by administration of its powder. Curcuma longa powder was applied to the animals, and it was followed by post treatment of the powder afterCurcuma longa powder on the hepatocyteKeywords: Turmeric, Aspartate Amino Transferase, Alanine Amino Transferase, Hepatocyte.Wistar male rats were used as experimental animals (n=6) in this study. Plasma Aspartate Amino Transferase(AST) and Alanine Amino Transferase (ALT) levels were measured before and 24 h, one week and two weeksafter i.p. injection of CCL4 (0.005 cc/kg), dissolved in liquid paraffin (0.5 cc/kg). In sham control group, animalswere treated only by the vehicle. To investigate the therapeutic effects of the turmeric, in post treatment group,animals were orally treated with turmeric rhizome powder (4 g/kg/day) after CCL4 injection. To investigate boththe protective and therapeutic effects of the turmeric in pre and post-treatment group, 15 days oral pretreatmentof CCL4 injection for several days. To investigate the protective effects of the turmeric in pre-treatment group,treatment was as same as the previous group, except the post treatment.In comparison to sham control, AST and ALT levels in the control group significantly increased 24 hrs after CCL4treatment and remained high until the last measurement (p< 0.001), but there were no significant differences betweensham control and other three groups. In the histophysiological study, vacuolar state, hepatocyte lipofication and necrosiswere chosen as hepatocytotoxicity criterions, in comparison to sham control group, hepatocytotoxicity was obvious, butthere were no hepatocytotoxicity in the pre- and pre+post-treated groups, 24 and 48 h after CCL4 injection.The results showed possible therapeutic and protective effects of damage induced by CCl4.(turmeric) powder is used abundantly as spice. Turmeric has also been traditionally applied
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نوع مقاله منتشر شده Original Research
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