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Physiology and Pharmacology، جلد ۹، شماره ۲، صفحات ۱۶۷-۱۷۲
عنوان فارسی The effects of intra-locus coeruleus injection of dopamine D۱ receptor agents on naloxone-induced withdrawal signs
چکیده فارسی مقاله I Mirzaii Dizgah1, SM Karimian1, MR Zarrindast2, H Sohanaki11. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Abstract:Opiate-induced addiction is one of the main problems of mankind societies and its treatment is one of the healthpriorities of community. Therefore, relative studies would be very crucial. The exact mechanism of dependenceto opiates and their withdrawal syndrome remain unclear. It seems that dopaminergic system and locus coeruleus(LC) have an important role in the somatic signs expression of opioids withdrawal syndrome. In the presentstudy, the effects of different D1 dopaminergic receptor agonist and antagonist administration into the LC on theexpression of withdrawal signs of morphine dependence in rats were studied.Rats were divided into 8 groups (n=8). Two cannulae were stereotaxically implanted bilaterally into the LC. After1 weak recovery, 7 groups rendered dependent to morphine (subcutaneously) during a 7 day period and nondependentanimals were received saline with the same protocol. Animals received bilateral intra-LC injections ofsaline, SKF38393 (D1 agonist) or SCH23390 (D1 antagonist) before naloxone injection about 24 hours after thelast dose of morphine or saline. Total withdrawal score as an index of withdrawal syndrome were decreased bySKF38393 (2, 4 μg/site) but not by SCH23390. It is concluded that the D1 dopaminergic system in the LC maybe involved in the morphine induced dependency in rats.Keywords: SCH23390.Withdrawal Syndrome, Dopamine, Morphine, dependence, Naloxone, Locus coeruleus, SKF38393,Physiology and Pharmacology7
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نوع مقاله منتشر شده Original Research
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