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Physiology and Pharmacology، جلد ۹، شماره ۲، صفحات ۲۰۳-۲۰۹
عنوان فارسی A۲C۸ and MC۲B۸ Monoclonal Antibodies Against Human Plasminogen inhibit Fibrinolytic System
چکیده فارسی مقاله A Maleki1, M Mirshahi2, AA Pourfathollah1 and K Mansouri11. Dep. Hematology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.2. Dep. Biochemistry, School of Basic Sciences, Tarbiat Modares University, Tehran, Iran.Abstract:In the present study the effects of two antiplasminogen monoclonal antibodies A2C8 and MC2B8 on the activationof the fibrinolytic system was studied.For this purpose, after separate steps like the culture of antibody producing hybridoma cells, their injection tomice, and purification of antibodies from ascites fluid, the effects of these antibodies was studied with variousmethods. Primary observation with pooled plasma showed that these antibodies in the presence of plasminogenactivators (t-PA, u-PA and SK) can inhibit the activation of fibrinolytic system. According the results obtainedfrom D-dimer assay, the inhibition effects of these antibodies is dose dependent. The other test that performedwith S-2251 synthetic substrate showed that the activation of plasminogen in the presence of Urokinase and in theresult, deterioration of this substrate was decreased in the presence of A2C8 and MC2B8 antibodies.In the present study we evaluated the effects and mechanism of two antiplasminogen monoclonal antibodies A2C8and MC2B8 on the activation of the fibrinolytic system in the presence of plasminogen activators.Keywords: Fibrinolytic system, Plasminogen, Monoclonal antibody, Plasminogen activators.
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عنوان انگلیسی
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نوع مقاله منتشر شده Original Research
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