این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۷، شماره ۲، صفحات ۱۴۳-۱۴۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Synergistic effect of 'Y-interferon and chemotherapeutic drugs on KE-37
چکیده انگلیسی مقاله Therapeutic use of biological response modulators in combination with chemotherapeutic drugs may propose a more efficient way for cancer therapy with fewer side effects. However, the related mechanism has not been well understood. Γ-interferon is a modulator of biological responses that inhibits the growth of malignant cells and mediates their differentiation. In this investigation, T cell lymphoblastic leukemia-derived cell line (KE-37) was used for studying the synergistic effect of interferon and chemotherapeutic agents. For this purpose, this cell line was grown in tissue culture flasks and transferred to 96 well plates. Various doses of vincristine, methylprednisolone and dounorubicin were added to culture medium and the cells were grown at 370 °C incubator with 5% CO2. Then, 100 IU/ml of γ -interferon was added to cell culture at different times (at hours 0, 8, 36, and 60). The synergistic effect of γ-interferon and above-mentioned drugs was measured through MTT assay. Our results suggest that y-interferon could significantly increase the cytotoxic and/or cytostatic effects of vincristine, methylprednisolone, and tiounorubicin (p< 0.05). In addition, this synergistic effect was more significant when γ-interferon was added 36 and 60 hours after addition of drugs (p< 0.05).
کلیدواژه‌های انگلیسی مقاله γ -interferon, Cell line, Chemotherapy
نویسندگان مقاله جواد آراسته | javad araste
department of immunology, school of medical sciences, tarbiat modares universtiy, tehran, i.r. iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

علی اکبر پورفتح اله | ali akbar pourfathollah
department of hematology, school of medical sciences, tarbiat modares universtiy, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

سید محمد موذنی | seyed mohammad moazzeni
department of immunology, school of medical sciences, tarbiat modares universtiy, tehran, i.r. iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

مسعود سلیمانی | masood soleimani
department of hematology, school of medical sciences, tarbiat modares universtiy, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-57-2&slc_lang=en&sid=en
فایل مقاله دریافت فایل مقاله
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات