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Iranian Biomedical Journal، جلد ۲۲، شماره ۵، صفحات ۳۳۸-۳۴۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Prevalence and Genotyping of Torque Teno Virus in HBV/HIV and Chronic HBV Patients in Iran
چکیده انگلیسی مقاله Background: Torque teno virus (TTV) was the first human Anelloviridae detected in a Japanese patient with an unknown type of hepatitis in 1997. TTV is by far the first known single-stranded circular DNA virus infecting human. In spite of its widespread nature in human population, its pathogenesis is still unclear. In addition, information regarding TTV infection in Iranian population is limited. Therefore, we attempted to determine the prevalence and genotype of TTV in three groups: HIV/HBV patients, chronic hepatitis B patients, and healthy individuals. Methods: The presence of TTV DNA in sera was investigated using PCR. The primer sets encompassing two 5΄-UTR and N22 regions were used, and the positive products were collected for sequencing. Phylogenetic tree was generated based on N22 region and using the MEGA 7 software. Results: TTV DNA was detected in 452 patients with HIV/HBV and chronic hepatitis B, as well as in healthy control groups. The results from PCR indicated positive rates ftrated ates positive rates Results, Conclusionffor these three groups, 48%, 54%, and 49.3% using 5΄-UTR primer and 15.1%, 12%, and 8% using N22 primer, respectively. Conclusion: Five genogroups were observed, which the second group was found to be the most frequent. The results of 5΄-UTR primer showed more prevalence of TTV DNA comparing to N22 primer in patients and healthy control.
کلیدواژه‌های انگلیسی مقاله Torque teno virus, HIV, Polymerase chain reaction, Iran
نویسندگان مقاله | Zahra Najafimemar
Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran


| Alijan Tabarraei
Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran


| Gholamreza Talei
Department of Microbiology, Faculty of Medicine, Lorestan University of Medical Sciences, Lorestan, Iran


| Abdolvahab Moradi
Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Golestan, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-709&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-625699.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Molecular Microbiology
نوع مقاله منتشر شده مقاله کامل
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