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Physiology and Pharmacology، جلد ۶، شماره ۱، صفحات ۲۷-۳۷
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عنوان انگلیسی Effect of locus ceruleus phasic electrical stimulation on responses of barrel cortical cells to controlled mechanical displacement in rats
چکیده انگلیسی مقاله Behavioral and electrophysiological evidences have shown that locus ceruleus (LC) is involved in different tasks including modulation of sensory processing and shift of attention. In the present study, single unit responses of barrel cortical cells was recorded following controlled mechanical displacement of the principal and peripheral vibrissae in adult rats (100 trials of 200 µm deflection for 10 ms at 1/1.5 second). Mechanical displacement was performed alone and 50 ms after electrical stimulation (10 pulses, 300 µs, 30 µA, 40 Hz) of LC. The onset of evoked responses was defined as the time when spontaneous activity exceeded its mean by two standard deviations. Then, analysis of response latency and response magnitude for periods of 10 and 50 ms following the initiation of evoked response was performed. Response magnitude to principal vibrissae deflection in a period of 10 ms decreased significantly after LC phasic stimulation (p< 0.01), but there was no significant difference for a period of 50 ms. In addition, for both time periods, there was no significant differences for response magnitude to peripheral vibrissae deflection before and after LC phasic stimulation. Response latency to principal vibrissae deflection increased significantly after LC stimulation, but it decreased significantly when peripheral vibrissae were deflected (p< 0.05). These results support the idea that LC phasic activation has an important role in cortical somatosensory information processing through modulating the receptive field characteristics of cortical neurons.
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نویسندگان مقاله ژیلا بهزادی | jila behzadi
department of physiology and neuroscience research center, school of medicine, shaheed beheshti university of medical sciences, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

وحید شیبانی | vahid sheibani


حسین استکی | hossein esteky


فرزانه گنجی | farzaneh ganji


نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-70-106&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research
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